NEDD8-MDP1

Across TCGA pan-cancer cohorts, NEDD8-MDP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NEDD8-MDP1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher NEDD8-MDP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NEDD8-MDP1 expression acts as an unfavorable survival marker, although some lineages such as THYM and MESO show a favorable association.

OV, BRCA, and KIRC are the cancer types where NEDD8-MDP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.633	0.737	.003	106	view →
BRCA	DFS	Quartile	All	0.913	0.971	<.001	98	view →
KIRC	OS	Tertile	II,III,IV	0.385	0.590	<.001	71	view →
LIHC	DFS	Quartile	II,III,IV	0.148	0.394	.003	65	view →
ACC	DFS	Median	All	0.506	0.807	<.001	56	view →
HNSC	DFS	Tertile	IV	0.302	0.674	.002	36	view →
UVM	DFS	Quartile	III,IV	0.269	0.815	.021	20	view →
BLCA	OS	Median	All	0.218	0.524	.004	20	view →
KIRP	DFS	Median	IV	0.039	0.470	.021	18	view →
SKCM	DFS	Median	All	0.574	0.663	.005	15	view →
THYM	OS	Median	II,III,IV	1.000	0.889	.011	15	view →
MESO	OS	Tertile	III,IV	0.621	0.145	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NEDD8-MDP1–OV (OS)

Open the OV breakdown →