NEDD4L

Across TCGA patient cohorts, NEDD4L RNA expression is significantly associated with the protein abundance of many other proteins, with 17,059 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NEDD4L-associated proteins across cancer lineages are NEDD4L_S446, TXNL1, and NEDD4L_S475. Each is linked with NEDD4L in more than 6 cancer types. Because this analysis shows association rather than direction, both NEDD4L-to-partner and partner-to-NEDD4L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD4L versus NEDD4L_S446 in BRCA, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4L→partner) and Y-score (partner→NEDD4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEDD4L_S446 →	+1.047	+0.787	<.001	<.001	3	7
LSCC	TXNL1 →	+0.374	+0.944	<.001	<.001	3	6
LSCC	NEDD4L_S475 →	+0.966	+0.842	<.001	<.001	3	6
LUAD	RELCH →	+0.233	+0.703	<.001	<.001	3	6
CCRCC	RIPK2 →	-0.420	-0.642	<.001	<.001	3	6
LSCC	NEDD4L_S449 →	+1.124	+0.879	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,059 associations by consensus.

NEDD4L vs NEDD4L_S446 — BRCA

Explore this scatter interactively →