NEDD4L

Across TCGA pan-cancer cohorts, NEDD4L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NEDD4L data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NEDD4L RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NEDD4L expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, READ, and UCS are the cancer types where NEDD4L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.761	0.513	<.001	139	view →
READ	DFS	Tertile	All	0.825	0.258	<.001	51	view →
UCS	DFS	Median	III,IV	0.493	0.143	.004	48	view →
LUAD	DFS	Median	All	0.423	0.234	.001	48	view →
KIRP	DFS	Tertile	All	0.939	0.787	<.001	46	view →
BRCA	DFS	Tertile	III,IV	0.960	0.838	.002	45	view →
ACC	DFS	Tertile	All	0.507	0.814	.001	45	view →
MESO	OS	Median	III,IV	0.437	0.672	.001	33	view →
COAD	DFS	Median	All	0.839	0.719	.006	26	view →
SKCM	OS	Tertile	IV	0.260	0.753	.001	21	view →
THCA	OS	Median	III,IV	1.000	0.904	.004	21	view →
OV	OS	Quartile	III,IV	0.933	0.823	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NEDD4L–KIRC (DFS)

Open the KIRC breakdown →