NEDD4L

Across TCGA pan-cancer cohorts, NEDD4L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NEDD4L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NEDD4L RNA is repressed in tumor relative to normal tissue. In most cancer types NEDD4L is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and KIRP are the cancer types where NEDD4L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEDD4L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.428	<.001	12	view →
LUAD	Female	II,III,IV	−1.590	<.001	11	view →
KIRP	Male	III,IV	−1.504	<.001	11	view →
KIRC	Male	II,III,IV	−1.265	<.001	11	view →
LIHC	Female	II,III,IV	+1.288	<.001	9	view →
HNSC	Male	III,IV	+1.249	<.001	8	view →
READ	Male	All	−1.353	<.001	6	view →
LUSC	All	II,III,IV	−0.865	<.001	6	view →
BRCA	Female	All	−0.361	<.001	4	view →
CHOL	All	All	+1.622	<.001	3	view →
PRAD	All	All	+0.969	<.001	2	view →
KICH	All	All	+0.612	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NEDD4L–COAD

Open the COAD breakdown →