NEDD4L

Across TCGA patient cohorts, NEDD4L protein abundance is significantly associated with the RNA expression of many other genes, with 15,814 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NEDD4L-associated genes across cancer lineages are RELCH, ATP8B1, and VPS4B. Each is linked with NEDD4L in more than 6 cancer types. Because this analysis shows association rather than direction, both NEDD4L-to-partner and partner-to-NEDD4L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD4L versus RELCH in LSCC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4L→partner) and Y-score (partner→NEDD4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RELCH →	+0.549	+0.545	<.001	<.001	3	7
BRCA	ATP8B1 →	+1.099	+0.488	<.001	<.001	3	6
LSCC	VPS4B →	+0.543	+0.448	<.001	<.001	3	6
LSCC	IER3IP1 →	+0.824	+0.419	<.001	<.001	3	6
HNSC	NARS1 →	+0.646	+0.402	.005	<.001	3	6
COAD	PIGN →	+0.647	+0.409	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,814 associations by consensus.

NEDD4L vs RELCH — LSCC

Explore this scatter interactively →