NEDD4L

Across TCGA patient cohorts, NEDD4L mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEDD4L-associated genes across cancer lineages are ATM, PDCD4, and INPP4B. Each is linked with NEDD4L in more than 3 cancer types. Because this analysis shows association rather than direction, both NEDD4L-to-partner and partner-to-NEDD4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NEDD4L-low versus NEDD4L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4L→partner) and Y-score (partner→NEDD4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.697	-2.146	<.001	<.001	3	4
UCEC	PDCD4 →	-0.393	-2.906	.004	.001	3	3
COAD	INPP4B →	-0.575	-3.000	.001	.034	3	3
UCEC	EGFR_pY1068 →	-0.264	-1.688	<.001	.001	3	2
UCEC	ERK2 →	+0.179	+1.485	.001	.003	3	2
UCEC	GATA6 →	-0.117	-2.570	.013	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by NEDD4L expression — UCEC

Explore this box plot interactively →