NEDD4L

Across TCGA cell cohorts, NEDD4L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,969 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NEDD4L-associated GO terms across cancer lineages are Positive regulation of caveolin-mediated endocytosis, Regulation of sodium ion import across plasma membrane, and Regulation of potassium ion export across plasma membrane. Each is linked with NEDD4L in more than 16 cancer types. Because this analysis shows association rather than direction, both NEDD4L-to-partner and partner-to-NEDD4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of caveolin-mediated endocytosis grouped by NEDD4L-low versus NEDD4L-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4L→partner) and Y-score (partner→NEDD4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of caveolin-mediated endocytosis →	+0.247	+1.700	<.001	<.001	3	17
BLOOD_Leukemia	Regulation of sodium ion import across plasma membrane →	+0.610	+1.365	<.001	<.001	3	15
STOMACH	Regulation of potassium ion export across plasma membrane →	+0.193	+1.300	<.001	.009	3	12
BONE	Negative regulation of protein localization to cell surface →	+0.243	+1.916	<.001	<.001	3	12
CNS	Negative regulation of potassium ion export across plasma membrane →	+0.230	+1.079	<.001	<.001	3	10
BLOOD_Myeloma	Regulation of caveolin-mediated endocytosis →	+0.171	+1.407	.001	.008	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,969 associations by consensus.

Positive regulation of caveolin-mediated endocytosis by NEDD4L expression — KIDNEY

Explore this box plot interactively →