NEDD4L

Across TCGA cell cohorts, NEDD4L mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEDD4L-associated genes across cancer lineages are CLC, CSN2, and KRT85. Each is linked with NEDD4L in more than 1 cancer types. Because this analysis shows association rather than direction, both NEDD4L-to-partner and partner-to-NEDD4L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLC grouped by NEDD4L-low versus NEDD4L-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4L→partner) and Y-score (partner→NEDD4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLC →	+1.156	+3.376	<.001	.009	3	2
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	KRT85 →	+0.473	+3.823	<.001	.006	3	1
LARGE_INTESTINE	MDGA2 →	+0.215	+3.854	<.001	.006	3	1
LARGE_INTESTINE	ZAN →	+0.010	+4.882	.001	<.001	3	1
LARGE_INTESTINE	PPDPFL →	+0.048	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

CLC by NEDD4L expression — LUNG_SCLC

Explore this box plot interactively →