NEDD4

Across TCGA patient cohorts, NEDD4 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,132 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NEDD4-associated proteins across cancer lineages are FRMD6, PPFIBP1, and PDLIM4. Each is linked with NEDD4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD4 versus FRMD6 in UCEC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FRMD6 →	+0.569	+0.940	<.001	<.001	3	6
BRCA	PPFIBP1 →	+0.389	+0.699	<.001	<.001	2	7
BRCA	PDLIM4 →	+0.589	+0.706	<.001	.002	3	6
OV	LRPPRC →	-0.397	-0.867	<.001	<.001	3	6
OV	TUBB6 →	+0.479	+0.789	<.001	<.001	3	5
PDAC	SEC23A →	+0.348	+0.456	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,132 associations by consensus.

NEDD4 vs FRMD6 — UCEC

Explore this scatter interactively →