NEDD4

Across TCGA pan-cancer cohorts, NEDD4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NEDD4 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NEDD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NEDD4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

MESO, KICH, and KIRC are the cancer types where NEDD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.250	0.523	<.001	80	view →
KICH	DFS	Tertile	All	0.626	1.000	.001	79	view →
KIRC	OS	Quartile	All	0.744	0.548	<.001	79	view →
LUAD	OS	Quartile	All	0.227	0.473	<.001	59	view →
SCLC	DFS	Median	All	0.527	1.000	<.001	39	view →
KIRP	DFS	Tertile	All	0.477	0.681	<.001	36	view →
LGG	OS	Tertile	All	0.434	0.664	<.001	36	view →
BLCA	DFS	Quartile	II,III,IV	0.243	0.454	.007	28	view →
STAD	OS	Quartile	II,III,IV	0.564	0.853	.007	27	view →
UVM	DFS	Quartile	II,III,IV	0.317	0.778	.008	21	view →
THYM	DFS	Quartile	II,III,IV	0.788	0.493	.008	19	view →
ACC	DFS	Quartile	All	0.482	0.858	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NEDD4–MESO (OS)

Open the MESO breakdown →