NEDD4

Across TCGA patient cohorts, NEDD4 mutation is significantly associated with the RNA expression of many other genes, with 5,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEDD4-associated genes across cancer lineages are RNA5SP88, ATP5F1B, and EBNA1BP2. Each is linked with NEDD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEDD4-to-partner and partner-to-NEDD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP88 grouped by NEDD4-low versus NEDD4-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD4→partner) and Y-score (partner→NEDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNA5SP88 →	+0.338	+5.266	<.001	.006	3	3
COAD	ATP5F1B →	+0.556	+3.740	<.001	<.001	3	3
LUAD	EBNA1BP2 →	+0.548	+3.459	<.001	.005	3	3
LUAD	EMC1 →	+0.464	+3.494	.009	.002	3	3
LUAD	C19orf57 →	+0.612	+3.482	.007	.002	3	3
UCEC	RPA1 →	+0.624	+2.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,754 associations by consensus.

RNA5SP88 by NEDD4 expression — LGG

Explore this box plot interactively →