NECTIN3

Across TCGA patient cohorts, NECTIN3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,866 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NECTIN3-associated genes across cancer lineages are TOP2A, ESPL1, and PARPBP. Each is linked with NECTIN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NECTIN3-to-partner and partner-to-NECTIN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NECTIN3 versus TOP2A in GBM, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN3→partner) and Y-score (partner→NECTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TOP2A →	-0.833	-0.361	<.001	<.001	3	3
GBM	ESPL1 →	-0.837	-0.495	<.001	<.001	3	3
GBM	PARPBP →	-0.573	-0.376	<.001	.001	3	3
GBM	KIFC1 →	-0.864	-0.470	.004	.002	3	3
GBM	TPX2 →	-0.855	-0.413	.004	.005	3	3
GBM	HEPH →	+0.962	+0.398	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,866 associations by consensus.

NECTIN3 vs TOP2A — GBM

Explore this scatter interactively →