NECTIN3

Across TCGA pan-cancer cohorts, NECTIN3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NECTIN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NECTIN3 RNA is repressed in tumor relative to normal tissue. In most cancer types NECTIN3 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUAD are the cancer types where NECTIN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NECTIN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.488	<.001	11	view →
THCA	Male	III,IV	−1.989	<.001	10	view →
LUAD	Female	II,III,IV	−1.130	<.001	7	view →
BRCA	All	III,IV	−1.245	<.001	6	view →
READ	All	All	−1.770	<.001	5	view →
LUSC	Male	II,III,IV	−1.175	<.001	5	view →
HNSC	All	All	+0.460	.013	3	view →
UCEC	All	III,IV	−1.221	.008	2	view →
PRAD	All	All	+0.869	<.001	2	view →
KIRP	All	All	+0.358	.038	2	view →
LIHC	Female	All	−0.453	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NECTIN3–COAD

Open the COAD breakdown →