NECTIN3

Across TCGA cell cohorts, NECTIN3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible NECTIN3-associated genes across cancer lineages are OR14K1, OR1C1, and UGT2B10. Each is linked with NECTIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NECTIN3-to-partner and partner-to-NECTIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by NECTIN3-low versus NECTIN3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NECTIN3→partner) and Y-score (partner→NECTIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR14K1 →	+0.200	+5.285	<.001	.003	3	2
STOMACH	OR1C1 →	+0.123	+5.285	<.001	.003	3	2
CNS	UGT2B10 →	+0.036	+4.321	<.001	.009	3	1
CNS	CD1C →	+0.034	+5.566	<.001	<.001	3	1
CNS	KRTAP2-2 →	+0.175	+4.832	<.001	.002	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR14K1 by NECTIN3 expression — STOMACH

Explore this box plot interactively →