NEB

Across TCGA patient cohorts, NEB mutation is significantly associated with the RNA expression of many other genes, with 11,414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEB-associated genes across cancer lineages are GBGT1, RAPGEF4, and MASTL. Each is linked with NEB in more than 6 cancer types. Because this analysis shows association rather than direction, both NEB-to-partner and partner-to-NEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBGT1 grouped by NEB-low versus NEB-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEB→partner) and Y-score (partner→NEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GBGT1 →	-0.560	-3.037	<.001	<.001	3	7
STAD	RAPGEF4 →	-0.374	-2.157	.003	.002	3	7
SKCM	MASTL →	+0.367	+0.883	<.001	<.001	3	6
UCEC	ZWINT →	+0.612	+1.321	<.001	<.001	3	6
UCEC	DLGAP5 →	+0.504	+0.988	<.001	<.001	3	6
LUAD	CEP85 →	+0.406	+1.608	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,414 associations by consensus.

GBGT1 by NEB expression — STAD

Explore this box plot interactively →