NEB

Across TCGA pan-cancer cohorts, NEB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NEB data layer compared with 14 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NEB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEB expression acts as an unfavorable survival marker, although some lineages such as LUSC and MESO show a favorable association.

KIRP, KICH, and LIHC are the cancer types where NEB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.769	0.942	<.001	112	view →
KICH	DFS	Quartile	All	0.568	0.930	.002	43	view →
LIHC	DFS	Median	All	0.466	0.616	<.001	42	view →
LGG	DFS	Median	All	0.673	0.800	<.001	36	view →
LUSC	OS	Tertile	II,III,IV	0.761	0.607	.005	31	view →
MESO	OS	Quartile	All	0.680	0.431	.010	30	view →
KIRC	DFS	Quartile	All	0.547	0.715	.006	28	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.180	.002	24	view →
UVM	DFS	Median	III,IV	0.259	0.748	.007	22	view →
HNSC	OS	Median	All	0.306	0.430	.011	20	view →
UCEC	DFS	Median	All	0.794	0.878	.003	18	view →
SCLC	DFS	Tertile	III,IV	0.233	0.817	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NEB–KIRP (DFS)

Open the KIRP breakdown →