NEB

Across TCGA pan-cancer cohorts, NEB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NEB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NEB RNA is repressed in tumor relative to normal tissue. In most cancer types NEB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where NEB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−1.292	<.001	10	view →
LIHC	All	II,III,IV	+0.994	<.001	9	view →
COAD	All	All	+0.353	<.001	9	view →
LUSC	All	II,III,IV	+0.720	<.001	8	view →
KICH	Male	All	−0.791	<.001	7	view →
KIRC	All	II,III,IV	+0.548	.005	7	view →
UCEC	All	All	+0.400	.002	6	view →
BLCA	All	All	+0.601	.007	5	view →
HNSC	Male	All	−1.932	.017	4	view →
CHOL	All	All	+1.562	.028	4	view →
STAD	All	All	+0.552	<.001	4	view →
LUAD	All	All	+0.294	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NEB–THCA

Open the THCA breakdown →