NEB

Across TCGA cell cohorts, NEB mutation is significantly associated with the RNA expression of many other genes, with 2,472 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEB-associated genes across cancer lineages are NUP54, C9orf92, and UBE2G1. Each is linked with NEB in more than 4 cancer types. Because this analysis shows association rather than direction, both NEB-to-partner and partner-to-NEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUP54 grouped by NEB-low versus NEB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEB→partner) and Y-score (partner→NEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP54 →	+0.462	+2.222	<.001	<.001	3	5
LUNG_NSCLC_LUAD	C9orf92 →	+0.068	+1.540	.003	.003	3	4
LARGE_INTESTINE	UBE2G1 →	+0.593	+1.215	<.001	<.001	3	4
BLOOD_Leukemia	KRAS →	+0.594	+2.674	.003	<.001	3	4
LARGE_INTESTINE	MMS22L →	+0.852	+1.994	<.001	<.001	3	4
LARGE_INTESTINE	ELP5 →	+0.651	+1.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,472 associations by consensus.

NUP54 by NEB expression — LARGE_INTESTINE

Explore this box plot interactively →