NDUFS8

Across TCGA patient cohorts, NDUFS8 mutation is significantly associated with the RNA expression of many other genes, with 203 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NDUFS8-associated genes across cancer lineages are PGAM5P1, NXNP1, and NLGN1-AS1. Each is linked with NDUFS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDUFS8-to-partner and partner-to-NDUFS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM5P1 grouped by NDUFS8-low versus NDUFS8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDUFS8→partner) and Y-score (partner→NDUFS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PGAM5P1 →	+0.050	+3.766	<.001	.005	3	2
SKCM	NXNP1 →	+0.038	+3.979	<.001	.003	3	2
SKCM	NLGN1-AS1 →	+0.160	+3.997	<.001	.003	3	2
LUAD	MIR607 →	+0.422	+5.444	<.001	.002	3	2
LUAD	RNU6-565P →	+0.383	+4.481	<.001	.009	3	2
UCEC	TRAJ12 →	+0.796	+3.318	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 203 associations by consensus.

PGAM5P1 by NDUFS8 expression — SKCM

Explore this box plot interactively →