NDUFS8

Across TCGA pan-cancer cohorts, NDUFS8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NDUFS8 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NDUFS8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NDUFS8 expression acts as an unfavorable survival marker, although some lineages such as KIRP and MESO show a favorable association.

KIRP, KIRC, and UVM are the cancer types where NDUFS8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.924	0.791	<.001	115	view →
KIRC	DFS	Tertile	All	0.829	0.926	<.001	97	view →
UVM	OS	Quartile	All	0.369	0.956	<.001	62	view →
HNSC	DFS	Tertile	All	0.642	0.757	.003	38	view →
UCS	DFS	Tertile	IV	0.484	0.932	.024	36	view →
LIHC	OS	Tertile	All	0.481	0.699	.001	35	view →
LGG	DFS	Median	All	0.669	0.800	<.001	34	view →
MESO	DFS	Quartile	III,IV	0.553	0.324	.018	33	view →
LAML	DFS	Tertile	All	0.303	0.558	.001	30	view →
ACC	OS	Tertile	IV	0.264	0.932	.001	25	view →
PRAD	DFS	Quartile	All	0.835	0.961	<.001	18	view →
READ	DFS	Quartile	All	1.000	0.662	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NDUFS8–KIRP (DFS)

Open the KIRP breakdown →