NDRG1

Across TCGA patient cohorts, NDRG1 mutation is significantly associated with the RNA expression of many other genes, with 5,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NDRG1-associated genes across cancer lineages are MTND2P30, RNU6-499P, and MVD. Each is linked with NDRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NDRG1-to-partner and partner-to-NDRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P30 grouped by NDRG1-low versus NDRG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NDRG1→partner) and Y-score (partner→NDRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND2P30 →	+0.056	+4.821	<.001	.003	3	2
BRCA	RNU6-499P →	+0.202	+7.471	<.001	.008	3	2
UCEC	MVD →	+0.515	+2.787	<.001	<.001	3	2
UCEC	DAPK3 →	+0.368	+2.091	.002	<.001	3	2
UCEC	HDGFL2 →	+0.356	+2.436	.003	.001	3	2
UCEC	CNNM3 →	+0.348	+2.638	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,231 associations by consensus.

MTND2P30 by NDRG1 expression — COAD

Explore this box plot interactively →