NDRG1

Across TCGA pan-cancer cohorts, NDRG1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NDRG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NDRG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NDRG1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where NDRG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NDRG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.147	<.001	12	view →
HNSC	Female	III,IV	+2.028	<.001	12	view →
THCA	Female	All	−0.895	<.001	10	view →
LIHC	Male	All	+1.369	<.001	8	view →
LUSC	Male	All	+1.649	<.001	6	view →
COAD	Female	II,III,IV	−1.272	<.001	6	view →
BRCA	All	All	−0.482	<.001	6	view →
CHOL	Male	All	+2.000	<.001	4	view →
KICH	All	All	−0.629	.022	4	view →
PAAD	All	All	+2.092	.019	2	view →
UCEC	All	All	−1.077	.011	2	view →
KIRP	Male	All	−0.958	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NDRG1–KIRC

Open the KIRC breakdown →