NCK1

Across TCGA patient cohorts, NCK1 mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCK1-associated genes across cancer lineages are OR5T3, LINC00459, and FAM96AP1. Each is linked with NCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCK1-to-partner and partner-to-NCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5T3 grouped by NCK1-low versus NCK1-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCK1→partner) and Y-score (partner→NCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	OR5T3 →	+0.039	+7.962	<.001	.007	3	2
CESC	LINC00459 →	+0.103	+4.669	<.001	.007	3	2
CESC	FAM96AP1 →	+0.089	+6.584	<.001	<.001	3	2
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
SKCM	APOOP3 →	+0.049	+5.212	<.001	.002	3	2
BLCA	RN7SKP107 →	+0.148	+6.040	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

OR5T3 by NCK1 expression — THCA

Explore this box plot interactively →