NCK1

Across TCGA pan-cancer cohorts, NCK1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NCK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NCK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NCK1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where NCK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NCK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.112	<.001	12	view →
KIRP	All	II,III,IV	+0.811	<.001	11	view →
LIHC	All	III,IV	+0.736	<.001	9	view →
THCA	All	II,III,IV	−0.520	<.001	9	view →
COAD	All	All	−0.430	<.001	8	view →
BRCA	All	All	−0.174	.003	6	view →
CHOL	All	All	+1.373	<.001	5	view →
LUSC	Male	All	+0.687	<.001	5	view →
HNSC	All	All	+0.492	.005	5	view →
KICH	Female	All	−1.093	<.001	4	view →
READ	All	All	−0.669	.020	2	view →
UCEC	All	All	−0.568	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NCK1–KIRC

Open the KIRC breakdown →