NCF1

Across TCGA patient cohorts, NCF1 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NCF1-associated genes across cancer lineages are MIR6780B, CCL27, and ZNF25-DT. Each is linked with NCF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NCF1-to-partner and partner-to-NCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780B grouped by NCF1-low versus NCF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NCF1→partner) and Y-score (partner→NCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6780B →	+0.799	+4.296	<.001	.008	3	2
UCEC	CCL27 →	+0.044	+4.470	<.001	.004	3	2
UCEC	ZNF25-DT →	+0.189	+2.764	.001	.004	3	2
UCEC	NDUFB9P1 →	+0.289	+2.781	<.001	.003	3	1
UCEC	F8A2 →	+0.036	+3.472	<.001	.004	3	1
UCEC	LTO1 →	+0.413	+3.223	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

MIR6780B by NCF1 expression — SKCM

Explore this box plot interactively →