NBEA

Across TCGA patient cohorts, NBEA mutation is significantly associated with the RNA expression of many other genes, with 6,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NBEA-associated genes across cancer lineages are ATP5F1B, CHCHD4, and TIMM21. Each is linked with NBEA in more than 6 cancer types. Because this analysis shows association rather than direction, both NBEA-to-partner and partner-to-NBEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1B grouped by NBEA-low versus NBEA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NBEA→partner) and Y-score (partner→NBEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP5F1B →	+0.350	+1.777	<.001	.002	3	6
STAD	CHCHD4 →	+0.315	+2.823	.003	.001	3	6
COAD	TIMM21 →	+0.472	+1.952	<.001	.002	3	6
STAD	GRPEL1 →	+0.462	+2.120	<.001	.002	3	5
STAD	CCDC86 →	+0.486	+1.597	<.001	.009	3	5
READ	AUNIP →	+0.758	+3.477	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,280 associations by consensus.

ATP5F1B by NBEA expression — COAD

Explore this box plot interactively →