NBEA

Across TCGA pan-cancer cohorts, NBEA RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NBEA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NBEA RNA is repressed in tumor relative to normal tissue. In most cancer types NBEA is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and THCA are the cancer types where NBEA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NBEA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.190	<.001	11	view →
BLCA	All	III,IV	−1.753	<.001	8	view →
THCA	Male	II,III,IV	−1.152	<.001	7	view →
LUSC	All	II,III,IV	−0.838	<.001	7	view →
UCEC	All	All	−2.329	<.001	6	view →
KICH	All	All	−0.717	.009	6	view →
READ	All	All	−1.818	<.001	5	view →
CHOL	All	All	+1.679	<.001	5	view →
STAD	All	All	−1.009	.006	4	view →
HNSC	All	All	−0.543	.008	4	view →
KIRC	Male	III,IV	−0.412	.031	2	view →
LIHC	Female	All	+0.346	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NBEA–COAD

Open the COAD breakdown →