NALCN

Across TCGA patient cohorts, NALCN RNA expression is significantly associated with the protein abundance of many other proteins, with 22,510 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NALCN-associated proteins across cancer lineages are PRELP, TMEM119, and MAP1A. Each is linked with NALCN in more than 8 cancer types. Because this analysis shows association rather than direction, both NALCN-to-partner and partner-to-NALCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NALCN versus PRELP in PDAC, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NALCN→partner) and Y-score (partner→NALCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRELP →	+1.049	+0.771	<.001	<.001	3	9
OV	TMEM119 →	+0.860	+0.423	<.001	<.001	3	9
HNSC	MAP1A →	+0.629	+0.446	<.001	<.001	3	9
BRCA	PHLDB1_S443 →	+0.583	+0.348	<.001	<.001	3	8
BRCA	PLXDC2 →	+0.662	+0.401	<.001	<.001	3	8
CCRCC	PODN →	+0.761	+0.566	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,510 associations by consensus.

NALCN vs PRELP — PDAC

Explore this scatter interactively →