NALCN

Across TCGA patient cohorts, NALCN protein abundance is significantly associated with the RNA expression of many other genes, with 5,911 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible NALCN-associated genes across cancer lineages are XBP1, MYH9, and CDS2. Each is linked with NALCN in more than 1 cancer types. Because this analysis shows association rather than direction, both NALCN-to-partner and partner-to-NALCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NALCN versus XBP1 in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NALCN→partner) and Y-score (partner→NALCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XBP1 →	-0.534	-0.904	.006	.006	3	1
GBM	MYH9 →	-0.729	-0.699	.005	.007	3	1
GBM	CDS2 →	+0.544	+0.995	<.001	<.001	3	1
GBM	SGCG →	+0.575	+0.785	.009	.007	3	1
GBM	HSF4 →	+0.762	+0.766	.007	.009	3	1
GBM	MEFV →	-0.641	-0.908	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,911 associations by consensus.

NALCN vs XBP1 — GBM

Explore this scatter interactively →