NALCN

Across TCGA patient cohorts, NALCN mutation is significantly associated with the RNA expression of many other genes, with 7,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NALCN-associated genes across cancer lineages are TIPRL, CCDC43, and NDUFAB1. Each is linked with NALCN in more than 5 cancer types. Because this analysis shows association rather than direction, both NALCN-to-partner and partner-to-NALCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPRL grouped by NALCN-low versus NALCN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NALCN→partner) and Y-score (partner→NALCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TIPRL →	+0.284	+1.206	.009	.007	3	6
UCEC	CCDC43 →	+0.396	+1.512	<.001	<.001	3	6
HNSC	NDUFAB1 →	+0.427	+2.607	<.001	.005	3	5
SKCM	SAR1A →	+0.271	+1.328	.004	<.001	3	5
BLCA	MRPL46 →	+0.349	+3.242	.002	.008	3	5
UCEC	MLX →	+0.412	+1.693	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,021 associations by consensus.

TIPRL by NALCN expression — SKCM

Explore this box plot interactively →