NAALADL2

Across TCGA cell cohorts, NAALADL2 mutation is significantly associated with the RNA expression of many other genes, with 1,161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAALADL2-associated genes across cancer lineages are GPR26, C10orf71, and SLC5A8. Each is linked with NAALADL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAALADL2-to-partner and partner-to-NAALADL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by NAALADL2-low versus NAALADL2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALADL2→partner) and Y-score (partner→NAALADL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	DMRTC2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	S100G →	+0.054	+4.867	.001	.009	3	1
LARGE_INTESTINE	PES1 →	+0.450	+2.800	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

GPR26 by NAALADL2 expression — OESOPHAGUS

Explore this box plot interactively →