NAALADL2

Across TCGA pan-cancer cohorts, NAALADL2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NAALADL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NAALADL2 RNA is repressed in tumor relative to normal tissue. In most cancer types NAALADL2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where NAALADL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAALADL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.371	<.001	12	view →
KICH	Male	All	−1.303	<.001	10	view →
LUAD	Female	II,III,IV	+1.005	<.001	8	view →
KIRP	Male	All	−0.969	<.001	7	view →
CHOL	All	All	+1.474	<.001	4	view →
UCEC	All	III,IV	−0.851	.017	4	view →
BRCA	Female	All	−0.354	.004	4	view →
LIHC	Male	All	−0.263	.031	3	view →
PRAD	All	All	+0.836	<.001	2	view →
LUSC	All	III,IV	−0.506	.038	1	view →
COAD	All	II,III,IV	−0.364	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NAALADL2–KIRC

Open the KIRC breakdown →