NAALAD2

Across TCGA patient cohorts, NAALAD2 mutation is significantly associated with the RNA expression of many other genes, with 3,339 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAALAD2-associated genes across cancer lineages are OIP5, RN7SL248P, and ATP5MGP6. Each is linked with NAALAD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NAALAD2-to-partner and partner-to-NAALAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by NAALAD2-low versus NAALAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALAD2→partner) and Y-score (partner→NAALAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.600	+2.075	<.001	<.001	3	4
BRCA	RN7SL248P →	+0.079	+5.201	<.001	.002	3	3
LIHC	ATP5MGP6 →	+0.429	+4.567	<.001	.004	3	3
HNSC	RN7SL134P →	+0.155	+3.725	<.001	.005	3	3
CESC	HMGB1P25 →	+0.083	+5.201	<.001	.007	3	3
UCEC	R3HCC1 →	+0.368	+1.797	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,339 associations by consensus.

OIP5 by NAALAD2 expression — UCEC

Explore this box plot interactively →