MYSM1

Across TCGA cell cohorts, MYSM1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYSM1-associated genes across cancer lineages are GPR42, S100A7A, and IFNL3. Each is linked with MYSM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYSM1-to-partner and partner-to-MYSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR42 grouped by MYSM1-low versus MYSM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYSM1→partner) and Y-score (partner→MYSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	S100A7A →	+0.056	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	IFNL3 →	+0.100	+5.209	.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.221	+3.252	.002	.009	3	1
LARGE_INTESTINE	OR2C1 →	+0.119	+3.841	<.001	.001	3	1
BLOOD_Leukemia	TMEM196 →	+0.036	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GPR42 by MYSM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →