MYPN

Across TCGA patient cohorts, MYPN protein abundance is significantly associated with the RNA expression of many other genes, with 2,193 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MYPN-associated genes across cancer lineages are CDK15, SPRY1, and FILIP1L. Each is linked with MYPN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYPN-to-partner and partner-to-MYPN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYPN versus CDK15 in HNSC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYPN→partner) and Y-score (partner→MYPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CDK15 →	+0.608	+1.109	<.001	<.001	3	2
LUAD	SPRY1 →	+0.974	+0.770	.003	.007	3	2
LUAD	FILIP1L →	+0.982	+0.672	<.001	.001	3	2
LUAD	SGCD →	+1.100	+0.716	.006	.009	3	2
HNSC	LINC00702 →	+0.697	+1.063	<.001	<.001	3	2
LSCC	PLPPR4 →	+0.873	+0.497	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,193 associations by consensus.

MYPN vs CDK15 — HNSC

Explore this scatter interactively →