MYPN

Across TCGA pan-cancer cohorts, MYPN RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MYPN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MYPN RNA is repressed in tumor relative to normal tissue. In most cancer types MYPN is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where MYPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.771	<.001	11	view →
LUAD	All	II,III,IV	+0.109	.006	7	view →
HNSC	Male	All	−1.528	.010	5	view →
READ	All	All	−0.686	<.001	5	view →
LIHC	All	All	+0.009	.005	3	view →
PAAD	All	All	+0.255	.045	2	view →
KIRC	Male	All	+0.024	<.001	2	view →
CHOL	Male	All	+0.016	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MYPN–COAD

Open the COAD breakdown →