MYOC

Across TCGA cell cohorts, MYOC mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYOC-associated genes across cancer lineages are MYH8, KCNIP1, and FSD2. Each is linked with MYOC in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOC-to-partner and partner-to-MYOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH8 grouped by MYOC-low versus MYOC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOC→partner) and Y-score (partner→MYOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYH8 →	+0.060	+2.657	.005	.007	3	1
LARGE_INTESTINE	KCNIP1 →	+0.040	+3.794	.005	.001	3	1
LARGE_INTESTINE	FSD2 →	+0.083	+3.743	<.001	.001	3	1
LARGE_INTESTINE	DCAF12L1 →	+0.007	+3.257	.002	.001	3	1
SKIN	OR2B2 →	+0.019	+4.684	.007	.002	3	1
LUNG_NSCLC_LUAD	OR11H1 →	+0.035	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MYH8 by MYOC expression — LARGE_INTESTINE

Explore this box plot interactively →