MYO7B

Across TCGA patient cohorts, MYO7B mutation is significantly associated with the RNA expression of many other genes, with 6,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO7B-associated genes across cancer lineages are UHRF1, GIT1, and GPI. Each is linked with MYO7B in more than 4 cancer types. Because this analysis shows association rather than direction, both MYO7B-to-partner and partner-to-MYO7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by MYO7B-low versus MYO7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO7B→partner) and Y-score (partner→MYO7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.825	+1.625	<.001	<.001	3	5
CESC	GIT1 →	+0.411	+2.351	<.001	.003	3	5
LUAD	GPI →	+0.419	+2.378	<.001	<.001	3	5
LUAD	LIG1 →	+0.409	+1.874	.001	.002	3	5
UCEC	CCDC86 →	+0.333	+1.588	.001	<.001	3	5
UCEC	FANCE →	+0.323	+1.245	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,185 associations by consensus.

UHRF1 by MYO7B expression — UCEC

Explore this box plot interactively →