MYO7B

Across TCGA pan-cancer cohorts, MYO7B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MYO7B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MYO7B RNA is repressed in tumor relative to normal tissue. In most cancer types MYO7B is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and LUAD are the cancer types where MYO7B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYO7B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.712	<.001	11	view →
BLCA	All	III,IV	−0.690	<.001	11	view →
LUAD	Female	III,IV	−1.506	<.001	9	view →
HNSC	All	II,III,IV	+0.447	.001	9	view →
LUSC	Female	All	−1.654	<.001	8	view →
LIHC	Female	All	+1.020	<.001	6	view →
BRCA	All	III,IV	−0.604	<.001	6	view →
UCEC	All	All	−0.429	.002	6	view →
COAD	Female	II,III,IV	−0.864	<.001	4	view →
STAD	All	II,III,IV	+1.647	.020	2	view →
PRAD	All	All	−0.214	<.001	2	view →
CHOL	All	II,III,IV	+0.104	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MYO7B–KICH

Open the KICH breakdown →