MYO1H

Across TCGA cell cohorts, MYO1H mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO1H-associated genes across cancer lineages are DAZ3, ACTRT1, and WFDC8. Each is linked with MYO1H in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO1H-to-partner and partner-to-MYO1H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ3 grouped by MYO1H-low versus MYO1H-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1H→partner) and Y-score (partner→MYO1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DAZ3 →	+0.630	+5.169	<.001	.004	3	1
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MAGEB5 →	+0.040	+4.906	<.001	.006	3	1
OESOPHAGUS	OR5B21 →	+0.023	+4.906	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	SPO11 →	+0.092	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

DAZ3 by MYO1H expression — BONE

Explore this box plot interactively →