MYL12B

Across TCGA patient cohorts, MYL12B mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL12B-associated genes across cancer lineages are IL3, RNA5SP286, and OR4C50P. Each is linked with MYL12B in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL12B-to-partner and partner-to-MYL12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by MYL12B-low versus MYL12B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL12B→partner) and Y-score (partner→MYL12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL3 →	+0.141	+5.357	<.001	.006	3	1
BLCA	RNA5SP286 →	+0.273	+7.640	<.001	.009	3	1
BLCA	OR4C50P →	+0.034	+7.640	<.001	.009	3	1
BLCA	RNA5SP420 →	+0.218	+7.640	<.001	.009	3	1
UCEC	MIR3154 →	+0.231	+5.414	<.001	.001	3	1
UCEC	ATP6V1E1P2 →	+0.409	+3.492	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

IL3 by MYL12B expression — COAD

Explore this box plot interactively →