MYL12B

Across TCGA pan-cancer cohorts, MYL12B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MYL12B data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MYL12B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MYL12B expression acts as an unfavorable survival marker, although some lineages such as THCA and KIRC show a favorable association.

HNSC, ACC, and THCA are the cancer types where MYL12B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.614	0.760	<.001	116	view →
ACC	DFS	Median	All	0.384	0.770	<.001	87	view →
THCA	OS	Median	III,IV	1.000	0.888	<.001	74	view →
UVM	DFS	Quartile	III,IV	0.176	0.832	<.001	69	view →
KIRC	OS	Quartile	All	0.742	0.507	<.001	57	view →
LGG	OS	Median	All	0.745	0.870	<.001	52	view →
UCEC	DFS	Median	IV	0.200	0.656	.001	36	view →
PAAD	DFS	Quartile	All	0.387	0.638	.004	32	view →
LIHC	OS	Tertile	All	0.726	0.859	.011	25	view →
LUAD	OS	Tertile	All	0.232	0.463	.010	23	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	18	view →
COAD	DFS	Median	II,III,IV	0.407	0.646	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MYL12B–HNSC (DFS)

Open the HNSC breakdown →