MYL12B

Across TCGA pan-cancer cohorts, MYL12B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MYL12B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MYL12B RNA is repressed in tumor relative to normal tissue. In most cancer types MYL12B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, BLCA, and LIHC are the cancer types where MYL12B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYL12B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.401	<.001	11	view →
BLCA	All	III,IV	+0.854	<.001	11	view →
LIHC	Male	II,III,IV	+1.062	<.001	8	view →
HNSC	All	III,IV	+0.454	.001	8	view →
LUAD	Female	II,III,IV	−0.511	<.001	7	view →
THCA	Male	All	+0.458	<.001	7	view →
STAD	All	All	+0.496	.001	6	view →
COAD	All	All	−0.455	<.001	6	view →
BRCA	All	All	+0.287	<.001	6	view →
CHOL	Male	All	+2.139	<.001	5	view →
ESCA	All	All	+1.144	.008	2	view →
KIRC	All	II,III,IV	−0.222	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MYL12B–KICH

Open the KICH breakdown →