MYH7B

Across TCGA patient cohorts, MYH7B mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH7B-associated genes across cancer lineages are 4E-BP1, FOXO3a_pS318_S321, and Cyclin-B1. Each is linked with MYH7B in more than 3 cancer types. Because this analysis shows association rather than direction, both MYH7B-to-partner and partner-to-MYH7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYH7B-low versus MYH7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH7B→partner) and Y-score (partner→MYH7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.282	+2.247	<.001	.001	3	4
SKCM	FOXO3a_pS318_S321 →	-0.098	-1.687	.043	.040	3	3
UCEC	Cyclin-B1 →	+0.477	+1.938	.001	.001	3	3
UCEC	eEF2 →	+0.296	+1.736	.001	.005	3	3
COAD	GAPDH →	+0.455	+2.012	.022	.017	3	3
UCEC	ACC1 →	+0.237	+1.125	.013	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

4E-BP1 by MYH7B expression — UCEC

Explore this box plot interactively →