MYH7B

Across TCGA pan-cancer cohorts, MYH7B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MYH7B data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MYH7B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MYH7B expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

COAD, ACC, and STAD are the cancer types where MYH7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.416	0.705	<.001	71	view →
ACC	DFS	Tertile	All	0.361	0.731	<.001	58	view →
STAD	OS	Median	II,III,IV	0.467	0.657	<.001	43	view →
BRCA	OS	Tertile	III,IV	0.896	0.737	.005	35	view →
KIRC	DFS	Median	II,III,IV	0.405	0.601	.005	33	view →
HNSC	DFS	Tertile	IV	0.755	0.589	.015	33	view →
SCLC	OS	Tertile	III,IV	0.838	0.442	.007	29	view →
SKCM	OS	Quartile	III,IV	0.619	0.325	.008	24	view →
PRAD	DFS	Tertile	All	0.834	0.943	<.001	18	view →
UVM	OS	Median	All	0.520	0.853	.022	17	view →
BLCA	OS	Quartile	All	0.587	0.383	.014	15	view →
CHOL	OS	Median	IV	0.208	0.948	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MYH7B–COAD (OS)

Open the COAD breakdown →