MYH13

Across TCGA patient cohorts, MYH13 mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH13-associated genes across cancer lineages are Chk1, Rad50, and BRCA2. Each is linked with MYH13 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYH13-to-partner and partner-to-MYH13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by MYH13-low versus MYH13-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH13→partner) and Y-score (partner→MYH13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Chk1 →	+0.245	+3.321	.001	.009	3	5
COAD	Rad50 →	-0.276	-3.459	<.001	.004	3	4
CESC	BRCA2 →	+0.179	+2.833	.005	.031	3	4
COAD	Caspase-7-cleavedD198 →	+0.982	+2.115	<.001	.017	3	4
LGG	TFRC →	+0.437	+2.855	.049	.034	3	4
COAD	Acetyl-a-Tubulin-Lys40 →	-0.542	-2.000	.001	.027	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

Chk1 by MYH13 expression — COAD

Explore this box plot interactively →