MYH13

Across TCGA pan-cancer cohorts, MYH13 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MYH13’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MYH13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYH13 is over-expressed in tumor, although a few such as HNSC and ESCA show the opposite, repressed pattern.

BRCA, HNSC, and KIRC are the cancer types where MYH13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYH13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	+0.218	<.001	6	view →
HNSC	All	All	−0.151	.004	6	view →
KIRC	All	All	+0.124	<.001	6	view →
ESCA	All	All	−0.421	.002	4	view →
LIHC	Male	All	+0.019	.019	3	view →
PRAD	All	All	+0.073	.004	2	view →
LUSC	Male	All	+0.068	.020	2	view →
LUAD	All	IV	+0.055	.008	2	view →
CHOL	All	All	+0.048	.020	2	view →
KICH	Female	All	−0.014	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MYH13–BRCA

Open the BRCA breakdown →