MYB

Across TCGA patient cohorts, MYB mutation is significantly associated with the RNA expression of many other genes, with 2,097 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYB-associated genes across cancer lineages are OR5BD1P, ERHP2, and RNU6ATAC30P. Each is linked with MYB in more than 2 cancer types. Because this analysis shows association rather than direction, both MYB-to-partner and partner-to-MYB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5BD1P grouped by MYB-low versus MYB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYB→partner) and Y-score (partner→MYB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5BD1P →	+0.062	+5.523	<.001	.001	3	3
LUSC	ERHP2 →	+0.154	+2.762	<.001	.005	3	3
LUSC	RNU6ATAC30P →	+0.271	+3.947	<.001	<.001	3	3
LUSC	PCNPP2 →	+0.136	+3.241	<.001	.005	3	3
LUSC	GLUD1P9 →	+0.070	+4.459	<.001	.003	3	3
LUSC	PRAMEF35P →	+0.113	+4.459	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,097 associations by consensus.

OR5BD1P by MYB expression — LUAD

Explore this box plot interactively →