MYB

Across TCGA pan-cancer cohorts, MYB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MYB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MYB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYB is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

BLCA, STAD, and BRCA are the cancer types where MYB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+1.451	<.001	11	view →
STAD	All	III,IV	+2.496	<.001	10	view →
BRCA	All	II,III,IV	+1.317	<.001	6	view →
KIRP	All	III,IV	+0.430	.002	6	view →
KIRC	Male	All	+0.311	<.001	6	view →
HNSC	Female	III,IV	−1.128	.008	3	view →
CHOL	Female	All	+0.380	.014	3	view →
UCEC	All	All	+0.896	.035	2	view →
PRAD	All	All	+0.827	<.001	2	view →
LIHC	All	All	+0.155	.025	2	view →
ESCA	Female	All	+2.080	.029	1	view →
LUSC	All	All	+0.706	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MYB–BLCA

Open the BLCA breakdown →