MXRA8

Across TCGA cell cohorts, MXRA8 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MXRA8-associated genes across cancer lineages are TCF21, NXPE4, and OR10R2. Each is linked with MXRA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXRA8-to-partner and partner-to-MXRA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by MXRA8-low versus MXRA8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXRA8→partner) and Y-score (partner→MXRA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.019	+4.705	<.001	.003	3	1
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+1.821	+4.551	<.001	.004	3	1
BLOOD_Leukemia	CLDN34 →	+0.067	+5.569	<.001	.001	3	1
LARGE_INTESTINE	SGSM3 →	+0.767	+3.212	.002	.006	3	1
LARGE_INTESTINE	PARK7 →	+0.462	+3.137	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

TCF21 by MXRA8 expression — BLOOD_Leukemia

Explore this box plot interactively →